Inflammation in cardiac amyloidosis: prognostic marker or therapeutic target?
نویسندگان
چکیده
منابع مشابه
YB-1: oncoprotein, prognostic marker and therapeutic target?
Hanahan and Weinberg have proposed the 'hallmarks of cancer' to cover the biological changes required for the development and persistence of tumours [Hanahan and Weinberg (2011) Cell 144, 646-674]. We have noted that many of these cancer hallmarks are facilitated by the multifunctional protein YB-1 (Y-box-binding protein 1). In the present review we evaluate the literature and show how YB-1 mod...
متن کاملPrognostic marker and target in prostate cancer
(ROS) are present in low amounts and their action can be effectively counteracted by the antioxidant system of the cells. However, cancer cells have higher ROS levels as a consequence of their increased metabolic activity, leading to a state of chronic oxidative stress. Increased levels of ROS are indeed involved in tumorigenesis and progression, conferring a growth advantage to malignant cells...
متن کاملXPO1, therapeutic … and prognostic target in sarcomas
In a recent issue of Oncotarget [1], Nakayama et al. showed the anti-tumor activity of selinexor, an inhibitor of exportin 1, against a wide variety of sarcoma preclinical models, including several pathological subtypes of soft tissue sarcomas (STS). STS, which amount to less than 2% of adult cancers are a heterogeneous disease with ~50 different pathological subtypes [2]. Surgery is the main t...
متن کاملGhrelin is a prognostic marker and a potential therapeutic target in breast cancer
Ghrelin and obestatin are gastrointestinal peptides, encoded by the same preproghrelin gene. Both are expressed in breast cancer tissue and ghrelin has been implicated in breast cancer tumorigenesis. Despite recent advances in breast cancer management the need for new prognostic markers and potential therapeutic targets in breast cancer remains high. We studied the prognostic impact of ghrelin ...
متن کاملLysophosphatidic acid acyltransferase-beta is a prognostic marker and therapeutic target in gynecologic malignancies.
Lysophosphatidic acid, the substrate for lysophosphatidic acid acyltransferase beta (LPAAT-beta), is a well-studied autocrine/paracrine signaling molecule that is secreted by ovarian cancer cells and is found at elevated levels in the blood and ascites fluid of women with ovarian cancer. LPAAT-beta converts lysophosphatidic acid to phosphatidic acid, which functions as a cofactor in Akt/mTOR an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Heart Failure
سال: 2017
ISSN: 1388-9842
DOI: 10.1002/ejhf.1062